Tantalum Nanoparticles Reinforced PCL Scaffolds Using Direct 3D Printing for Bone Tissue Engineering

Polycarbonate (PCL) has been widely used in tissue engineering, but its hydrophobicity and low biological activity limit further promotion application. By adding nanoparticles, the hydrophilicity of PCL can be improved. In this study, different amounts Ta (1–10%wt) were added to PCL, then their mechanical properties studied vitro . XRD found that 5%Ta-PCL highest crystallinity. At same time, cell experiments CCK8, adhesion, osteogenic differentiation, osteogenesis related gene expression showed enhance while 5% Ta-PCL best properties. This composite tantalum could have a clinical potential for orthopedic implants.